Cooking garlic with meat appears to reduce the production of carcinogenic (cancer-causing) chemicals that can occur in meat as a result of cooking methods, such as grilling, that expose meat to high temperatures. Research presented at the American Association for Cancer Research's Frontiers in Cancer Prevention Research meeting in Baltimore, MD, suggests that the phytonutrient responsible for garlic's pungency may help prevent cancer by inhibiting the effects of one such carcinogen called PhIP.
A cancer-causing heterocyclic amine, PhIP is thought to be one reason for the increased incidence of breast cancer among women who eat large quantities of meat because it is rapidly transformed into DNA-damaging compounds.Diallyl disulphide (DAS), an organosulfur compound that gives garlic its unique flavor, has been shown to inhibit the transformation of PhIP into carcinogens. DAS blocks this transformation by decreasing the production of the liver enzymes (the Phase I enzymes CYP1A1, CYP1A2 and CYP1B1) that transform PhIP into activated DNA-damaging compounds.
In addition, DAS signals the genes responsible for producing two protective antioxidant enzymes, (glutathione-S-transferase (GST) and superoxide dismutase (SOD), which help protect the body against harmful compounds such as those produced from PhIP. These findings suggest that making garlic, onion, chives and other Allium vegetables, all of which contain DAS, a staple part of your healthiest way of eating may help in preventing breast cancer induced by PhIP in well-done meats. And enjoying these DAS-rich foods may help protect the men you love as well. Consumption of Allium vegetables has also been associated with a reduced risk of prostate cancer.
A cancer-causing heterocyclic amine, PhIP is thought to be one reason for the increased incidence of breast cancer among women who eat large quantities of meat because it is rapidly transformed into DNA-damaging compounds.Diallyl disulphide (DAS), an organosulfur compound that gives garlic its unique flavor, has been shown to inhibit the transformation of PhIP into carcinogens. DAS blocks this transformation by decreasing the production of the liver enzymes (the Phase I enzymes CYP1A1, CYP1A2 and CYP1B1) that transform PhIP into activated DNA-damaging compounds.
In addition, DAS signals the genes responsible for producing two protective antioxidant enzymes, (glutathione-S-transferase (GST) and superoxide dismutase (SOD), which help protect the body against harmful compounds such as those produced from PhIP. These findings suggest that making garlic, onion, chives and other Allium vegetables, all of which contain DAS, a staple part of your healthiest way of eating may help in preventing breast cancer induced by PhIP in well-done meats. And enjoying these DAS-rich foods may help protect the men you love as well. Consumption of Allium vegetables has also been associated with a reduced risk of prostate cancer.
