Grape OPCs linked to preventing LDL cholesterol

New research has linked oligomeric proanthocyanidins (OPCs) from grape seeds to preventing the LDL cholesterol oxidation that can lead to atherosclerosis.
Research performed in The Netherlands was presented this week at the 14th Annual Meeting of the Society for Free Radical Biology and Medicine in Washington DC. For the study, the scientists used Masquelier's original OPCs from IBioCeuticals in the US.
"The results of the first phase of the project are extremely promising, because they indicate that OPCs, at levels found in circulation after oral intake, are capable of protecting LDL from oxidation, and appear to be more effective protectors than vitamin E," said author Dr. Geetha Achanta,
Anthogenol, the Vitis vinifera seed extract found in Masquelier's OPCs is a rich source of antioxidants including catechins and 2-5 flavan-3-ols.
Achanta presented the results garnered from the study - entitled Oligomeric proanthocyanidins effectively inhibit LDL oxidation: a mechanistic study using a lipophilic oxidation-sensitive, fluorescent probe - at the annual meeting. The aim of the project, conducted at the Center for Cellular Architecture and Dynamics Department at the University of Utrecht, was to investigate how OPCs protect the vascual wall and potentially reduce the risk of cardiovascular health complications.
According to Achanta, in the previous year the team also found that OPCs can protect endothelial cells in the blood vessels from oxidative damage - thereby reducing the risk on endothelial dysfunction and vascular disorders.
"Targeting ROS [reactive oxygen species] with dietary antioxidants is therefore an attractive approach for preventing atherosclerosis, and this approach is supported by epidemiological evidence correlating dietary antioxidant intake with lower risk of cardiovascular disease," indicate the authors in the poster presentation.
As part of the study, human LDL (low density lipoprotein) cholesterol was isolated and labeled with C11-biodipy, a fluorescent lipophyllic probe whose fluorescence shifts from red to green upon oxidation.
The OPCs were then added to the control study and found to have an effect on LDL oxidation.
The results revealed a likely mechanism by which the OPCs protect LDL from oxidation. This is by scavenging free radicals generated in both the water phase, as well as the lipid phase that causes oxidation of the lipid-rich LDL particles and triggers inflammation.
Free radicals play a role in the onset of vascular inflammatory processes that can lead to deadly diseases such as angina and heart attacks.
The researchers are calling for further investigation into OPCs' potential to ward off such conditions.

Red wine may kill cancer cells

The antioxidant resveratrol, found in grape skins and red wine, can cripple the function of pancreatic cancer cells while sensitising them to chemotherapy, says new research.
Resveratrol is known for its ability to protect plants from bacteria and fungi, while previous research has also found it helps prevent the negative effects of high-calorie diets and has anti-inflammatory and anti-cancer potential.
While this study, published this month in Advances in Experimental Medicine and Biology, looked at the way the antioxidant may aid pancreatic cancer treatment, it also contributes to the growing knowledge on the health benefits arising from ingredients of red wine.
As well as disabling the function of the cancer cells by reaching and reacting with the mitochondria (the cell's energy source), researchers found that when they were pre-treated with resveratrol before being irradiated, it resulted in a type of cell death called apoptosis. This is an important goal of cancer therapy.
"Antioxidant research is very active and very seductive right now," said Paul Okunieff, chief of radiation oncology at the University of Rochester Medical Centre.

Bitter Melon juice improved blood glucose

I wanted to share with you about a natural plant ingredient that will help you lower your blood sugar level: Bitter Melon. This cucumber-like plant grows throughout Asia, Africa, and South America and is widely hailed both in folk medicine circles and from scientific investigation for its ability to lower blood sugar levels.Two ounces of bitter melon juice improved blood glucose levels in 73% of Type 2 diabetics tested. Another study gave 15 grams of extract from bitter melon to produce a 54% drop in after meal (post-prandial) blood glucose and 17% reduction in glycosylated hemoglobin.That's why I have included Bitter Melon extract as an important part of Melabic. To find out how Bitter Melon and 8 more diabetes fighting ingredients can help you.

Curcumin may aid cancer fight

A potentially potent treatment for the most lethal of cancers, pancreatic, may be right under the noses of people eating Indian curry.University of Alabama at Birmingham researchers are exploring the possibility that curcumin, which is found naturally in Indian curry powder, may inhibit the growth of pancreatic cancer and greatly
increase its susceptibility to chemotherapy treatment.But it's a little more complicated than heading out to an Indian restaurant.Mei Wan, a cellular pathologist at UAB, outlined the project this week for the American Cancer Society in Alabama, which is funding much of the work.Wan said the project started by looking at pancreatic cancer cells and noticing that a tumor suppressor called SMAD4 was missing. The main suspect was a protein called JAB1, which they found in excess.So researchers started searching for something to inhibit production
of JAB1, hoping that by eliminating this protein, they would enhance the body's natural ability to fight off cancer with SMAD4.The most effective JAB1 inhibitor was curcumin, which is found in Indian curry powder, which is easy to work with in trials with animals and humans. "It's quite safe and it's not toxic," Wan said.Pancreatic cancer kills 99 percent of patients who have it, most of them within a year of diagnosis. About 35,000 Americans die from it annually. "It is the deadliest among all malignancies, " Wan said.But while curcumin has shown promise in the lab, it's not soluble in water, which makes it difficult to inject, and it has a short half-life, meaning it is expelled from the body before it has a chance to really do its work.Now researchers have developed an experimental drug called PEG-curcumin, which "works really well" in mice, Wan said.Lab tests have shown that PEG-curcumin greatly enhances one of the few existing treatments for pancreatic cancer, the chemotherapy agent gemcitabine, and creates a cocktail that is even more promising than PEG-curcumin alone, Wan said. But it still must be tested in human trials.